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The differences are simply that oxycodone is an opioid substance that is the main ingredient in a number of pain medications (including OxyContin) and that OxyContin is the time-release version of oxycodone.Buy Here Oxycontin 30 & Save 10% Extra  It is 50 times more potent than heroin. It is a synthetic opioid that is often prescribed after surgery to treat severe pain. However, it has become a very popular street drug of abuse.Is oxycodone stronger than hydrocodone?Another study found that the combination of oxycodone and acetaminophen was 1.5 times more potent than hydrocodone with acetaminophen when taken at equal doses.Order OxyContin overnight without extra charge